So many awesome local projects: MAP (Massachusetts Avenue Project), The Wash Project, Essex Street Art Center, the Foundry, the Buffalo Infringement Festival, etc
Innovative local events/businesses: City of Night, Tour de Farms, Five Points Bakery, Elmwood-Bidwell Producers-only Farmers Market, West Side Bazaar, etc.
Cohesive neighborhoods: Allentown, Elmwood Village, Hertel (Little Italy), Grant Street, Parkside
History/Architecture: Delaware Park/Parkway System, Forest Lawn, Richardson-Olmsted Complex, not to mention downtown
Growing green movements, very bikeable (due to GOBike Buffalo's efforts)